Lei Ran,* Shi-Ya Peng,* Wei Wang, Qian Wu, Yuan-Chao Li, Ru-Peng Wang Department of Rheumatology and Dermatology, Xinqiao Hospital, Third Military Medical University of Chinese PLA, Chongqing, 430037, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ru-Peng Wang, Department of Rheumatology and Dermatolo
A novel expression system based on engineered variants of the yeast (Saccharomyces cerevisiae) dsRNA virus L-A was developed allowing the in vivo assembly of chimeric virus-like particles (VLPs) as a unique platform for a wide range of applications.We show that polypeptides fused to the viral capsid protein Gag self-assemble into isometric VLP chim
Abstract Induced oncoproteins degradation provides an attractive anti-cancer modality.Activation of anaphase-promoting complex (APC/CCDH1) prevents cell-cycle entry by targeting crucial mitotic proteins 5 Piece Round Table Dining Room for degradation.Phosphorylation of its co-activator CDH1 modulates the E3 ligase activity, but little is known abou
Colorectal cancer (CRC) continues to be one of the most prevalent and lethal cancers worldwide.Over the past decades, immune checkpoint inhibitors (ICIs) have shown to significantly improve patient outcomes in mismatch repair-deficient metastasized CRC.However, widening the scope of this novel treatment modality has been the object of growing inter